The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 16, 2004
Filed:
Feb. 25, 2000
Applicant:
Inventors:
John Leonard, Manchester, NH (US);
Samuel Goldman, Acton, MA (US);
Richard O'Hara, Jr., Quincy, MA (US);
Assignee:
Genetics Institute, LLC, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/9395 ; A61K 3/940 ; A61K 3/944 ; C21P 2/108 ; C07K 1/600 ;
U.S. Cl.
CPC ...
A61K 3/9395 ; A61K 3/940 ; A61K 3/944 ; C21P 2/108 ; C07K 1/600 ;
Abstract
Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-&ggr; or TNF-&agr;. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.