The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 09, 2004
Filed:
Nov. 24, 1999
Palani Balu, Cupertino, CA (US);
Other;
Abstract
Novel peptide dimers are provided that bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist. The novel compounds have a first peptide chain R and a second peptide chain R , wherein R and R may be the same or different, and are linked through a linking moiety. R is approximately 10 to 40 amino acid residues in length and comprises the sequence X X X GPX TX X X (SEQ ID NO: 1) wherein X is C or Hoc, X is R, H, L or W, X is M, F, I or nor-leucine (J), X is any one of the 20 genetically coded L-amino acids or J, X is W, 1-naphthylalanine (B) or 2-naphthylalanine (U), X is D, E, 1, L or V, and X is C or Hoc. Similarly, R comprises the sequence X′ X′ X′ GPX′ TX′ X′ X′ (SEQ ID NO: 2) wherein X′ is C or Hoc, X′ is R, H, L or W, X′ is M, F, I or J, X′ is any one of the 20 genetically coded L-amino acids or J, X′ is W, B or U, X ′ is D, E, I, L or V, and X′ is C or Hoc. Methods for synthesizing the compounds are provided as well, as are pharmaceutical compositions and methods of use.