The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2004
Filed:
Jun. 23, 2000
Applicant:
Inventors:
Steve R. Roffler, Taipei, TW;
Kuang-Wen Liao, Taipei, TW;
Assignee:
Academia Sinica, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/800 ; C07K 1/400 ; C12P 2/108 ; C12N 5/06 ; C12N 5/02 ;
U.S. Cl.
CPC ...
A61K 3/800 ; C07K 1/400 ; C12P 2/108 ; C12N 5/06 ; C12N 5/02 ;
Abstract
A chimeric protein expressed from a transgene tranduced into a mammalian tumor cell and method of using the chimeric protein for cancer treatment. The chimeric protein comprises an effector and an anchor, which are linked by a spacer. The chimeric protein, when expressed and exposed on the tumor cell surface in vivo can activate T cells, which further lead to lysis of the tumor cells. The anti-tumor effects can be enhanced by co-expression of certain co-stimulators, such as CD80 or CD86.