The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2004
Filed:
Mar. 10, 1994
Applicant:
Inventors:
Nancy H. Colburn, Middletown, MD (US);
Zigang Dong, Frederick, MD (US);
Powel H. Brown, North Potomac, MD (US);
Michael J. Birrer, Potomac, MD (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 4/304 ; A61K 3/170 ;
U.S. Cl.
CPC ...
A01N 4/304 ; A61K 3/170 ;
Abstract
The inhibition of AP-1 activity by dominant negative deletion mutants of c-jun is disclosed. This inhibition of AP-1 activity is shown to be associated with inhibition of tumor promoter-induced neoplastic transformation. Therefore, the invention relates to the utilization of dominant negative deletion mutants of c-jun which are inhibitory to tumor promotor-induced neoplastic transformation as therapeutic agents in the prevention and treatment of cancer in mammals.