The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 02, 2004
Filed:
Jan. 06, 2000
Applicant:
Inventors:
Pramathesh Patel, Thorndale, PA (US);
David Lach, Andalusia, PA (US);
Assignee:
Bristol-Myers Squibb Co., Princeton, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/500 ; C12N 1/509 ; C12N 1/564 ; C12Q 1/68 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C12N 1/500 ; C12N 1/509 ; C12N 1/564 ; C12Q 1/68 ; C07H 2/104 ;
Abstract
The invention relates to a prokaryotic cell system for monitoring protease activity. The invention also includes assays for identifying protease inhibitors and protease modulators, determining the amino acid sequence of a protease cleavage site for a known protease, identifying and cloning a protease whose cleavage site is known, and rapidly identifying a form of a protease exhibiting increased activity relative to a control protease.