The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2004
Filed:
Dec. 20, 2001
Martin W. Brechbiel, Annandale, VA (US);
Kim Deal, Springfield, VA (US);
Abstract
The present invention provides an &agr;-particle-emitting radioisotope chelation complex comprising Actinium ( Ac) and 1,4,7,10,13,16-hexaazacyclohexadecane-N,N′,N″,N′″,N″″,N′″″-hexaacetic acid (HEHA) ( Ac-HEHA). Also provided is a bifunctional HEHA, and a bifunctional Ac-HEHA. The bifunctional HEHA and the bifunctional Ac-HEHA can be conjugated to a targeting agent. In view of the above, the present invention provides a method of making HEHA and methods of making a bifunctional HEHA, including a conjugate thereof. Also provided are a method of treating disease, a method of treating cancer, a method of decontaminating a sample from Ac, a method of decontaminating a person who has been externally contaminated with Ac, and a method of detoxifying a person who has internalized Ac.