The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2004
Filed:
Sep. 20, 2002
Marc Thommen, Toffen, SE;
Andreas Hafner, Gelterkinden, SE;
Roman Kolly, Allschwil, SE;
Hans-Jörg Kirner, Pratteln, SE;
Frédéric Brunner, Chézard, SE;
Ciba Specialty Chemicals Corporation, Tarrytown, NY (US);
Abstract
Described is a process for the preparation of compounds of formula (1a) which comprises reacting an isomeric mixture consisting of from 75 to 95% of compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, to form a sertraline-imine isomeric mixture consisting of from 75 to 95% of formula (1a) and from 5 to 25% of formula (1b)(A ), or reacting an isomeric mixture consisting of from 75 to 95% of a compound of formula (2a) and from 5 to 25% of a compound of formula (2b) with methylamine, in a suitable solvent, using suitable methods of isolation to form an enriched sertraline-imine isomeric mixture, consisting of >99% of a compound of formula (1a) and <1% of a compound of formula (1b)(A ); and then subjecting the sertraline-imine isomeric mixture obtained according to reaction route (A ) or (A ), in a suitable solvent, to recrystallisation (B), in accordance with scheme (I) wherein in formula (1a), R , R and R are each independently of the others hydrogen, halogen, trifluoromethyl or C -C alkoxy and formulae (1b), (2a) and (2b) are as defined in the description.