The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2004
Filed:
Mar. 21, 2001
Applicant:
Inventors:
De-Chao Yu, Foster City, CA (US);
Yuanhao Li, Palo Alto, CA (US);
Andrew S. Little, Santa Ana, CA (US);
Daniel R. Henderson, Palo Alto, CA (US);
Assignee:
Cell Genesys, Inc., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 2/106 ; C12P 7/00 ; C12P 1/500 ; C12N 5/10 ; C12N 7/02 ; C12N 1/586 ;
U.S. Cl.
CPC ...
C12P 2/106 ; C12P 7/00 ; C12P 1/500 ; C12N 5/10 ; C12N 7/02 ; C12N 1/586 ;
Abstract
Disclosed herein are replication-competent adenovirus vectors comprising co-transcribed first and second genes under transcriptional control of a heterologous, target cell-specific transcriptional regulatory element (TRE), wherein the second gene is under translational control of an internal ribosome entry site. Methods for the preparation and use of such vectors are also provided. The vectors provide target cell-specific virus replication in applications such as cancer therapy and gene therapy.