The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 10, 2004

Filed:

Jun. 17, 2002
Applicant:
Inventors:

Roger John Butlin, Macclesfield Cheshire, GB;

Janet Elizabeth Pease, Macclesfield Cheshire, GB;

Michael Howard Block, Macclesfield Cheshire, GB;

Thorsten Nowak, Macclesfield Cheshire, GB;

Jeremy Nicholas Burrows, Macclesfield Cheshire, GB;

Assignee:

AstraZeneca AB, Sodertalje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ; C07C / ; A61K 3/116 ;
U.S. Cl.
CPC ...
C07C / ; C07C / ; A61K 3/116 ;
Abstract

A compound of formula (I) wherein: n is 1 or 2; R is chloro, fluoro, bromo, methyl or methoxy; R is as defined within; R is as defined within; and R is hydrogen or fluoro; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof is described. The use of compounds of formula (I) in the production of an elevation of PDH activity in a warm-blooded animal such as a human being are also described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are detailed.


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