The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 10, 2004
Filed:
Oct. 05, 1998
Applicant:
Inventors:
Richard T. Cummings, Fanwood, NJ (US);
David E. Moller, Watchung, NJ (US);
Jeffrey D. Hermes, Warren, NJ (US);
Gaochao Zhou, Scotch Plains, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 3/353 ; G01N 3/3533 ; G01N 3/3566 ;
U.S. Cl.
CPC ...
G01N 3/353 ; G01N 3/3533 ; G01N 3/3566 ;
Abstract
Provided is a method of identifying agonists and antagonists of nuclear receptors that comprises measuring agonist-dependent fluorescence resonance energy transfer (FRET) between a fluorescently labeled nuclear receptor or ligand binding domain and fluorescently labeled CREB-binding protein (CBP), p300, other nuclear co-activator, or binding portion thereof. The method is simple, rapid, and inexpensive. Nuclear receptors and nuclear receptor co-activators labeled with fluorescent reagents for use in the above-described method are also provided.