The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2004
Filed:
Dec. 02, 2002
Gerrit Herman Veeneman, Schaijk, NL;
Eduard Willem De Zwart, Oss, NL;
Hubert Jan Jozef Loozen, Uden, NL;
Jordi Mestres, Edinburgh, GB;
Akzo Nobel N.V., Arnhem, NL;
Abstract
The invention provides non-steroidal estrogenic compounds with estrogenic and anti-estrogenic compounds effects for treatment of estrogen-deficiency related disorders, which compounds are having formula (I) wherein, one of R or R is 'R ; R and 'R are OH, optionally independently etherified or esterified; X is N or —C(R )—, wherein R is H halogen, CN, optionally substituted aryl, (1C-4C)alkyl, (2C-4C)alkenyl, (2C-4C)alkynyl or (3C-6C)cycloalkyl, which alkyl, alkenyl, alkynyl and cycloalkyl groups can optionally be substituted with one or more halogens; Y is N or —C(R )—, with the proviso that X and Y are not both N, wherein R has the same meaning as defined for R ; Z is C(R ,'R )— or —C(R ,∝R )—C(R ,'R )—, wherein R , 'R , R , 'R , R , and 'R , independently arc H, (1C-4C)alkyl, (2C-4C)alkenyl or (3C-6C) cycloalkyl, which alkyl, alkenyl and cycloalkyl groups can optionally be substituted with one or more halogens. These compounds are useful for estrogen-receptor related treatments in view of a desirable profile of activity for estrogen &agr; and estrogen &bgr; receptors.