The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 03, 2004
Filed:
Jun. 27, 2001
Marcel Behr, Montreal, CA;
Peter Small, Stanford, CA (US);
Gary Schoolnik, Stanford, CA (US);
Michael A. Wilson, Stanford, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Specific genetic deletions are identified in mycobacteria isolates, including variations in the genome sequence between isolates, and numerous deletion present in BCG as compared to . These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from or to attenuate the pathogenic bacteria.