The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2004
Filed:
Oct. 09, 1996
Applicant:
Inventors:
Scott M. Silbiger, Woodland Hills, CA (US);
Raymond A. Koski, Old Lyme Road, CT (US);
Assignee:
Amgen Inc., Thousand Oaks, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/00 ; C07K 1/400 ; C12N 9/64 ;
U.S. Cl.
CPC ...
C07K 1/00 ; C07K 1/400 ; C12N 9/64 ;
Abstract
The present invention reveals a class of novel inhibitors of metalloproteinase. For convenience, these polypeptides are referred to as “TIMP-3”, as these polypeptides represent a new class of members of the tissue inhibitors of metalloproteinases. Also provided are DNA sequences coding for all or part of the TIMP-3s, vectors containing such DNA sequences, and host cells transformed or transfected with such vectors. In addition, methods of producing recombinant TIMP-3s, methods of treating disorders, pharmaceutical compositions including TIMP-3s and antibodies selectively binding TIMP-3s are provided.