The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 27, 2004
Filed:
Oct. 19, 1999
Applicant:
Inventors:
Robert J. Powell, Baltimore, MD (US);
George K. Lewis, Baltimore, MD (US);
David M. Hone, Ellicott City, MD (US);
Assignee:
University of Maryland, Baltimore, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 6/300 ; A61K 4/800 ; C12N 1/587 ; C12N 1/563 ; C12N 5/00 ;
U.S. Cl.
CPC ...
A01N 6/300 ; A61K 4/800 ; C12N 1/587 ; C12N 1/563 ; C12N 5/00 ;
Abstract
A method for introducing and expressing genes in animal cells is disclosed comprising infecting the animal cells with live invasive bacteria, wherein the bacteria contain a eukaryotic expression cassette encoding the gene. The gene may encode, e.g., a vaccine antigen, a therapeutic agent, an immunoregulatory agent or an anti-sense RNA or a catalytic RNA.