The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2004
Filed:
Aug. 16, 1999
Applicant:
Inventors:
Hermann Oppermann, Medway, MA (US);
Mei-Sheng Tai, Shrewsbury, MA (US);
John McCartney, Holliston, MA (US);
Assignee:
Stryker Corporation, Kalamazoo, MI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/400 ; C07K 1/4495 ; C12N 1/500 ; L12N 1/562 ; A61K 3/800 ;
U.S. Cl.
CPC ...
C07K 1/400 ; C07K 1/4495 ; C12N 1/500 ; L12N 1/562 ; A61K 3/800 ;
Abstract
The invention provides modified proteins and DNAs of the TGF-&bgr; superfamily including modified morphogenic proteins. The proteins of the present invention display altered biological or biochemical attributes. Specifically, the modified proteins are designed through substitutions of amino acids in the finger 2 sub-domain or exchanges of all or part of the finger 2 sub-domain of one TGF-&bgr; superfamily member with the finger 2 sub-domain of another TGF-&bgr; superfamily member.