The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 13, 2004

Filed:

Nov. 06, 1998
Applicant:
Inventors:

Michele Sanicola-Nadel, Winchester, MA (US);

Catherine Hession, Hingham, MA (US);

Richard L. Cate, Cohasset, MA (US);

Dane S. Worley, Somerville, MA (US);

Assignee:

Biogen, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 2/106 ; A61K 3/800 ; C07K 2/00 ; C07K 4/00 ; C07K 5/00 ;
U.S. Cl.
CPC ...
C12P 2/106 ; A61K 3/800 ; C07K 2/00 ; C07K 4/00 ; C07K 5/00 ;
Abstract

Nucleotide and amino acid sequences are provided for compounds which promote tissue growth, as well as methods for modulating tissue growth, for imaging tissues and organs, and for treating patients. Isolated nucleic acid and amino acid sequences for Ret ligands are disclosed. Ret ligands encoded by the isolated nucleic acid sequences of the invention have a hydrophobic N-terminal signal sequence, a hydrophobic C-terminal sequence and a phosphatidylinositol glycan linkage motif. Vectors and host cells that include Ret ligands encoded by the isolated nucleic acid sequences of the invention are also disclosed.


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