The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 06, 2004
Filed:
Oct. 26, 2000
Marca Henriëtte Michaela Wauben, Almere, NL;
Willem Van Eden, Bilthoven, NL;
Upither B.V., CL Utrecht, NL;
Abstract
The invention provides a peptide suitable for the prophylaxis, treatment, diagnosis or monitoring of arthritis. The peptide contains a contiguous sequence element of 9 amino acid residues (nonapeptide), having the amino acid sequence: X1-X2-X3-X4-X5-X6-X7-X8-X9. In the sequence, X2, X6 and X7 are any amino acid; X1 is any amino acid except K, H, R, E, D; X3 is S or T; X4 is one of F, L, I, V, A, G, C, P; X5 is one of A, G, C, P, S, N, T, V; X8 is one of V, L, I, M; and X9 is E or D. The peptide is also a part of a mammalian cartilage, joint or arthritis-related protein such as collagen or a cartilage protein, and is between 9-20 amino acids in length. Furthermore, the peptide is recognised by freshly isolated T cells from rats in which Adjuvant Arthritis is induced and/or is recognised in vitro by T cell clone A2