The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2003
Filed:
Oct. 04, 2001
Gloria A. Breault, Macclesfield, GB;
Stewart R. James, Macclesfield, GB;
Janet E. Pease, Macclesfield, GB;
AstraZeneca AB, Sodertalje, SE;
Abstract
A pyrimidine derivative of formula (I) wherein V is O or S, Q and Q are independently selected from phenyl, naphthyl, a 5- or 6-membered monocyclic moiety and a 9- or 10-membered bicyclic heterocyclic moiety; and Q is substituted by one substituent of formula (Ia), and Q may optionally bear further substituents of formula (Ia) wherein X is CH —, O—, NH—, NR — or —S—[wherein R is as defined within]; Y is H, C alkyl or as defined for Z; Y is H or C alkyl; Z is R O—, R R N—, R S—, R R NNR —, a nitrogen linked heteroaryl or a nitrogen linked heterocycle, wherein R , R , R , R , R , R and R are as defined within; n is 1, 2 or 3; m is 1, 2 or 3; and Q and Q may optionally be further substituted; or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof; are useful as anti-cancer agents; and processes for their manufacture and pharmaceutical compositions containing them are described.