The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 30, 2003
Filed:
Dec. 14, 1999
Ping Chen, San Diego, CA (US);
Mark Anderson, San Diego, CA (US);
Ya-Li Deng, San Diego, CA (US);
Smita Gaur, San Diego, CA (US);
Chen Chen Kan, Arcadia, CA (US);
Chun Luo, San Diego, CA (US);
Karen Lundgren, San Diego, CA (US);
Stephen Margosiak, Escondido, CA (US);
Binh Nguyen, San Diego, CA (US);
Patrick O'Connor, San Diego, CA (US);
James Register, San Diego, CA (US);
Anna Tempczyk Russell, San Diego, CA (US);
Jay Sarup, San Diego, CA (US);
Agouron Pharmaceuticals, Inc., San Diego, CA (US);
Abstract
The present invention relates to the identification, isolation and purification of the catalytic domain of the human effector checkpoint protein kinase (hChk1). A 1.7Å crystal structure of the hChk1 kinase domain in the active conformation is reported herein. The kinase domain of hChk1 and its associated crystal structure is described for use in the discovery, identification and characterization of inhibitors of hChk1. This structure provides a three-dimensional description of the binding site of the hChk1 for structure-based design of small molecule inhibitors thereof as therapeutic agents. Inhibitors of hChk1 find utility in the treatment of hyperproliferative disorders such as HIV and cancer.