The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2003
Filed:
Oct. 24, 1997
Applicant:
Inventors:
Micah S. Siegel, Berkeley, CA (US);
Ehud Y. Isacoff, Berkeley, CA (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/400 ; A61K 3/802 ; A61K 3/817 ; C07H 2/104 ;
U.S. Cl.
CPC ...
C07K 1/400 ; A61K 3/802 ; A61K 3/817 ; C07H 2/104 ;
Abstract
A chimeric protein sensor including an optically active polypeptide linked to a responsive polypeptide, or responsive fragment thereof, which undergoes a change in response to a cell signaling event, wherein an optical property of the sensor is altered in response to the change in the responsive polypeptide, or responsive fragment thereof is provided, as well as nucleic acid sequences encoding the chimeric protein sensor. The chimeric protein sensor includes an optically active polypeptide or fragment thereof, such as green fluorescent protein (GFP), for measuring cellular events in vivo.