The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 2003
Filed:
Sep. 24, 1999
Kyriacos C. Nicolaou, La Jolla, CA (US);
Yun He, San Diego, CA (US);
Sacha Ninkovic, San Diego, CA (US);
Joaquin Pastor, Madrid, ES;
Frank Roschangar, Durham, NC (US);
Francisco Sarabia, Torre De Benagalbón, ES;
Hans Vallberg, Huddinge, SE;
Dionisios Vourloumis, Apex, NC (US);
Nicolas Winssinger, La Jolla, CA (US);
Zhen Yang, Brookline, MA (US);
Nigel Paul King, Camborne, GB;
M. Ray Finlay, Killinchy, GB;
The Scripps Research Institute, La Jolla, CA (US);
Abstract
Epothilone A, epothilone B, analogs of epothilone and libraries of epothilone analogs are synthesized. Epothilone A and B are known anticancers agents that derive their anticancer activity by the prevention of mitosis through the induction and stabilization of microtubule assembly. The analogs of epothilone are novel. Several of the analogs are demonstrated to have a superior cytotoxic activity as compared to epothilone A or epothilone B as demonstrated by their enhanced ability to induce the polymerization and stabilization of microtubules.