The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2003
Filed:
Mar. 26, 1999
Howard P. Baden, Cambridge, MA (US);
Pamela Olson, Chestnut Hill, MA (US);
Marie-France Champliaud, Boston, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention relates to novel epidermal protein, sciellin. Sciellin polypeptides comprise an N-terminal domain, a central domain containing sixteen repeats and a C-terminal LIM domain. Sciellin polypeptides may function as precursors of the cornified envelope of keratinizing tissues. Described herein are isolated and antisense nucleic acids molecules, recombinant expression vectors, host cells and non-human transgenic animals containing an insertion or a disruption of the sciellin gene. Diagnostic, screening and therapeutic methods utilizing the compositions of the invention are also provided.