The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2003
Filed:
Mar. 14, 2001
Ovidiu Platica, New York, NY (US);
Other;
Abstract
This invention is directed to a method for detecting base changes in a nucleic acid of interest which comprise the following steps: (a) contacting the nucleic acid of interest with a suitable reference nucleic acid under suitable conditions that the nucleic acid of interest forms a heteroduplex with the reference nucleic acid; (b) contacting the heteroduplex with a combination of suitable nucleases so as to selectively cleave the heteroduplex if a base change(s) is present; (c) ligating a detectable probe to the cleaved heteroduplex; and (d) detecting the ligated probe under suitable conditions so as determine the location and the sequence of the base changes. The invention also includes kits for practicing the method. Also included are methods of identifying polymophisms associated with particular cancers.