The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 02, 2003
Filed:
Jun. 28, 2001
Atushi Kajiyama, Shizuoka, JP;
Tetsuya Tamura, Shizuoka, JP;
Takao Mizumoto, Shizuoka, JP;
Hitoshi Kawai, Shizuoka, JP;
Tatsuya Takahashi, Shizuoka, JP;
Yamanouchi Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
The present invention pertains to a quick disintegrating tablet in buccal cavity, characterized in that drug-containing particles with a mean particle diameter of approximately 50˜approximately 250 &mgr;m and an apparent specific gravity of approximately 0.5˜approximately 1.2 consisting of a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier and obtained by spray drying are added to a quick disintegrating tablet in buccal cavity comprising a drug and saccharide. Moreover, the present invention pertains to a method for manufacturing drug-containing particles having a specific mean particle diameter and specific apparent gravity by dissolving and suspending a bitter tasting drug and/or drug of inferior fluidity and a pharmaceutical preparation carrier (preferably containing water-insoluble polymer, particularly at least aqueous ethyl cellulose suspension (preferably containing plasticizer)) to a high concentration in terms of solid concentration in a solvent that is pharmaceutically acceptable and then spray drying this liquid using a rotating disk-type spray dryer, with the disk operating at low speed, and a method for manufacturing a quick disintegrating tablet in buccal cavity comprising said particles.