The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 25, 2003
Filed:
Sep. 18, 2000
Applicant:
Inventors:
Nicholas M. Dean, Olivenhain, CA (US);
Eric G. Marcusson, San Diego, CA (US);
Jacqueline Wyatt, Encinitas, CA (US);
Assignee:
ISIS Pharmaceuticals, Inc., Carlsbad, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 2/104 ; C07H 2/102 ; C12N 1/585 ; C12N 1/586 ; C12Q 1/68 ;
U.S. Cl.
CPC ...
C07H 2/104 ; C07H 2/102 ; C12N 1/585 ; C12N 1/586 ; C12Q 1/68 ;
Abstract
Compounds, compositions and methods are provided for inhibiting Fas mediated signaling. The compositions comprise antisense compounds targeted to nucleic acids encoding Fas, FasL and Fap-1. Methods of using these antisense compounds for inhibition of Fas, FasL and Fap-1 expression and for treatment of diseases, particularly autoimmune and inflammatory diseases and cancers, associated with overexpression or constitutive activation of Fas, FasL or Fap-1 are provided.