The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6649775 B1

PDF
Full Text
Expired
Date of Patent:
Nov. 18, 2003

Filed:

Jul. 23, 2002
Applicant:
Inventors:

Kwang-Hyeg Lee, Seongnam Si, KR;

Jin-Wan Kim, Seoul, KR;

Myeong-Sik Yoon, Yongin Si, KR;

Kwang-Do Choi, Anyang Si, KR;

Sang-Ho Lee, Anyang Si, KR;

Hong-Suk Cho, Icheon Si, KR;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ;
U.S. Cl.
CPC ...
C07D / ;
Abstract

The present invention relates to a process for preparing lovastatin and simvastatin which comprises (1) performing step of a lactonization of mevinic acid and analog thereof compounds in the presence of a dehydrating agent and without an acid catalyst under nitrogen sweep; and then (2) making step of crystals at a high temperature. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced in an amount remarkably. Therefore, the process of the present invention is convenient and economical.


Find Patent Forward Citations

Lee, Kwang-Hyeg. (2003). Process of lactonization in the preparation of statins (U.S. Patent No. 6649775). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6649775

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