The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 18, 2003
Filed:
Nov. 19, 1999
Mark W. Orme, Seattle, WA (US);
Nand Baindur, Edmonds, WA (US);
Kirk G. Robbins, Rendon, WA (US);
Scott M. Harris, Seattle, WA (US);
Maria Kontoyianni, Seattle, WA (US);
Laurence H. Hurley, Austin, TX (US);
Sean M. Kerwin, Round Rock, TX (US);
Gregory Mundy, San Antonio, TX (US);
Charles Petrie, Woodinville, WA (US);
Other;
Abstract
Compounds containing two aromatic systems covalently linked through a linker containing one or more atoms, or “linker” defined as including a covalent bond per se so as to space the aromatic systems at a distance 1.5-15 Å, are effective in treating conditions associated with bone deficits. The compounds can be administered to vertebrate subjects alone or in combination with additional agents that promote bone growth or that inhibit bone resorption. They can be screened for activity prior to administration by assessing their ability to effect the transcription of a reporter gene coupled to a promoter associated with a bone morphogenetic protein and/or their ability to stimulate calvarial growth in model animal systems.