The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 04, 2003
Filed:
Nov. 21, 2000
James R. Tata, Westfield, NJ (US);
Kevin T. Chapman, Scotch Plains, NJ (US);
Joseph Leslie Duffy, Cranford, NJ (US);
Nancy J. Kevin, East Brunswick, NJ (US);
Yuan Cheng, Edison, NJ (US);
Thomas A. Rano, Somerville, NJ (US);
Fengqi Zhang, Edison, NJ (US);
Tracy Huening, Madison, NJ (US);
Brian Anthony Kirk, Basking Ridge, NJ (US);
Zhijian Lu, Clinton, NJ (US);
Subharekha Raghavan, Teaneck, NJ (US);
Fred J. Fleitz, Franklin Park, NJ (US);
Daniel E. Petrillo, Hoboken, NJ (US);
Joseph D. Armstrong, III, Westfield, NJ (US);
Richard J. Varsolona, Scotch Plains, NJ (US);
David Askin, Warren, NJ (US);
R. Scott Hoerrner, Westfield, NJ (US);
Robert Purick, Edison, NJ (US);
Merck & Co., Inc., Rahway, NJ (US);
Abstract
&ggr;-Hydroxy-2-(fluoroalkylaminocarbonyl)-1-piperazinepentanamide compounds are inhibitors of HIV protease and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. These compounds are effective against HIV viral mutants which are resistant to HIV protease inhibitors currently used for treating AIDS and HIV infection.