The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 28, 2003

Filed:

Dec. 30, 1999
Applicant:
Inventors:

Michael W. Deem, Los Angeles, CA (US);

Marco Falcioni, Santa Clara, CA (US);

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 3/348 ; G01N 3/100 ; G01N 3/3566 ; G01N 3/3543 ; G01N 3/3536 ; C12Q 1/00 ; C12Q 1/68 ;
U.S. Cl.
CPC ...
G01N 3/348 ; G01N 3/100 ; G01N 3/3566 ; G01N 3/3543 ; G01N 3/3536 ; C12Q 1/00 ; C12Q 1/68 ;
Abstract

Methods for generating multiple rounds of combinatorial libraries, which use Monte Carlo methods to search the multi-dimensional composition and non-composition space of variables in combinatorial chemistry; the combinatorial libraries generated and screened by such Monte Carlo methods; and an apparatus for generating and screening such libraries robotically. The process involves preparing a first set of samples, then changing the composition and non-composition variables of the samples using Monte Carlo sampling methods, and accepting proposed new samples according to a detailed balance acceptance criterion.


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