The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 28, 2003
Filed:
Jun. 29, 2000
Hong Li, Epinay sur Seine, FR;
He Lu, Epinay sur Seine, FR;
Frank Griscelli, Paris, FR;
Paule Opolon, Paris, FR;
Claudine Soria, Taverny, FR;
Thierry Ragot, Meudon, FR;
Yves Legrand, Paris, FR;
Jeannette Soria, Taverny, FR;
Christelle Mabilat, Corbeil Essonnes, FR;
Michel Perricaudet, Ecrosnes, FR;
Patrice Yeh, Gif sur Yvette, FR;
Gencell SAS, Vitry sur Seine, FR;
Abstract
The present invention relates to gene therapy for the treatment of tumors. The invention more particularly relates to introduction of a gene encoding an anti-angiogenic factor into cells of a tumor, for example with a defective adenovirus vector, to inhibit growth or metastasis, or both, of the tumor. In a specific embodiment, delivery of a defective adenovirus that expresses the amino terminal fragment of urokinase (ATF) inhibited growth and metastasis of tumors. These effects were correlated with a remarkable inhibition of neovascularization within, and at the immediate vicinity of, the injection site. Delivery of a defective adenovirus vector that expresses kringles 1 to 3 of angiostatin inhibited tumor growth and tumorigenicity, and induced apoptosis of tumor cells. The invention further provides viral vectors for use in the methods of the invention.