The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 21, 2003

Filed:

Apr. 10, 2001
Applicant:
Inventors:

Jia-He Li, Cockeysville, MD (US);

Dana Victor Ferraris, Towson, MD (US);

Paul W. Kletzly, Arlington, VA (US);

Weixing Li, Ellicott City, MD (US);

Eric Yanjun Wang, Ellicott City, MD (US);

Amy D. Xing, Ellicott City, MD (US);

Weizheng Xu, Ellicott City, MD (US);

Jie Zhang, Ellicott City, MD (US);

Assignee:

Guilford Pharmaceuticals, Inc., Baltimore, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ;
U.S. Cl.
CPC ...
C07C / ;
Abstract

Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.


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