Phenoxyphenylheterocyclyl derivatives as ssris

Abstract

The invention provides compounds of general formula (I) wherein R is H or C -C alkyl; R and R , together with the interconnecting atoms form a 4 to 8-membered saturated ring containing one or two heteroatoms (including the nitrogen to which R is attached) wherein a second heteroatom, if present, is selected from oxygen, nitrogen and sulfur, with the proviso that said ring cannot contain two adjacent heteroatoms; Z is CF , OCF , C -C alkylthio or C -C alkoxy; Y is hydrogen, halogen, —OR , R or C -C alkylthio, and wherein R is C -C alkyl optionally substituted with fluorine atoms; or when Z and Y are attached para and meta to the ether linkage linking rings A and B, Z and Y are linked so that, together with the interconnecting atoms, Z and Y form a fused 5 to 7-membered carbocyclic or heterocyclic ring which may be saturated, unsaturated or aromatic, and wherein when Z and Y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; and Z and Y together do not form a fused phenyl ring; R and R , which may be the same or different, are: A—X, wherein A=—CH═CH— or —(CH ) — where p is 0, 1 or 2; X is hydrogen, F, Cl, Br, I, CONR R , SO NR R , SO NHC(═O)R , OH, C alkoxy, NR SO R , NO , NR R , CN, CO R , CHO, SR , S(O)R or SO R ; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R ; wherein R is hydroxy, C -C alkoxy, F, C -C alkyl, haloalkyl, haloalkoxy, —NH , —NH(C -C alkyl) or —N(C -C alkyl) .