The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 30, 2003
Filed:
May. 26, 1998
Stephen Kohl Doberstein, San Francisco, CA (US);
Darren Mark Platt, San Francisco, CA (US);
Kimberly Carr Ferguson, Pacifica, CA (US);
Andrew Roy Buchman, Berkeley, CA (US);
Sheila Akiko Homburger, Oakland, CA (US);
Exelixis, Inc., South San Francesco, CA (US);
Abstract
The present invention relates to insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.