The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 30, 2003

Filed:

May. 10, 2000
Applicant:
Inventors:

Sharat Singh, San Jose, CA (US);

Vivian Xiao, San Jose, CA (US);

Ian Gibbons, Portola Valley, CA (US);

Travis Boone, Oakland, CA (US);

Torleif Ove Bjornson, Gilroy, CA (US);

Herbert H. Hooper, Belmont, CA (US);

Edwin F. Ullman, Atherton, CA (US);

Assignee:

Aclara BioSciences, Inc., Mountain View, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 3/353 ; G01N 2/100 ;
U.S. Cl.
CPC ...
G01N 3/353 ; G01N 2/100 ;
Abstract

Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the atmosphere of a small volume in a zone, where a sample is placed in the zone where evaporation can occur. The zone is maintained in contact with a liquid medium that serves to replenish the liquid in the zone and maintain the composition of the mixture in the zone substantially constant. The diffusion of components in the zone is restricted during the course of the determination by the liquid flux into the zone.


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