The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6617423 B1

Date of Patent:

Sep. 09, 2003

Filed:

Dec. 20, 2000

Superpotent calcitonin analogs having greatly increased hypocalcemic action in vivo

Applicant:

Inventors:

Afroditi Kapurniotu, Tubingen, DE;

Jurgen Bernhagen, Tubingen, DE;

Herwig Brunner, Stuttgart, DE;

Assignee:

Fraunhofer-Gesellschaft zur Forderung der Angewandten Forschung E.V., Munich, DE;

Attorney:

Barnes & Thornburg

Primary Examiner:

Michael Borin

Int. Cl.

CPC ...

A61K 3/823 ;

U.S. Cl.

CPC ...

A61K 3/823 ;

Abstract

Calcitonins and calcitonin derivatives such as are employed for therapy for, for example, osteoporosis. Paget's disease or hypercalcemia. The calcitonins and calcitonin derivatives are distinguished by a bridging of the amino acids present in the positions 17 and 21. In this case, by means of a suitable choice of the amino acids present in these positions an 18- or 19-membered ring is produced. This ring leads to an increased conformational stability and to an increased activity of the modified calcitonin. A particularly suitable hCt (human Ct) analog is the cyclo -[Asp , Orn ]-hCt according to the invention having a 19-membered ring structure between the lactam-bridged Asp and Orn .

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