The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2003
Filed:
Nov. 28, 2000
Applicant:
Inventors:
Jeffrey Porter, Belmont, MA (US);
Oivin M. Guicherit, Belmont, MA (US);
Lee Rubin, Wellesley, MA (US);
Anthony David Baxter, Abingdon, GB;
Edward Andrew Boyd, Didcot, GB;
Stephen Price, Aylesbury, GB;
Assignee:
Curis, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 3/138 ; A61K 4/360 ; A61K 3/1505 ; A61K 3/1445 ;
U.S. Cl.
CPC ...
A61K 3/138 ; A61K 4/360 ; A61K 3/1505 ; A61K 3/1445 ;
Abstract
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. and In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.