The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2003
Filed:
Mar. 05, 2002
Applicant:
Inventors:
Joseph P Dougherty, Hampton, NJ (US);
Martin E Adelson, Hillsborough, NJ (US);
Malvika Kaul, Piscataway, NJ (US);
AnnMarie L Pacchia, Piscataway, NJ (US);
Yacov Ron, East Brunswick, NJ (US);
Assignee:
University of Medicine and Dentistry of New Jersey, New Brunswick, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/08 ; C12N 5/10 ; C12N 1/386 ;
U.S. Cl.
CPC ...
C12N 5/08 ; C12N 5/10 ; C12N 1/386 ;
Abstract
Novel packaging cell lines for production of lentiviral vectors are disclosed. The cell lines utilize an ecdysone-inducible system for virus production, thereby avoiding the cytotoxic effect of unregulated expression of certain envelope proteins and lentiviral proteins. Various embodiments of the cell lines are disclosed, which are suitable for different purposes that range from in vitro screening assays to gene therapy in vivo.