The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 2003
Filed:
Oct. 19, 1999
Gopalakrishna R. Vaddi, Hockessin, DE (US);
Ross L. Stein, Sudbury, MA (US);
Lawrence R. Dick, Natick, MA (US);
Vito J. Palombella, Needham, MA (US);
Eric S. Lightcap, Natick, MA (US);
Peter J. Elliott, Marlboro, MA (US);
Julian Adams, Brookline, MA (US);
Teresa A. McCormack, Medford, MA (US);
Stephen J. Brand, Lincoln, MA (US);
Dan R. Burns, Skillman, NJ (US);
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Abstract
The invention relates to methods for measuring proteasome activity in biological samples. More particularly, then invention relates to methods for monitoring drug action following in vivo administration of a proteasome inhibitor. The invention provides methods and kits for monitoring pharmacodynamic drug action and for determining dose regimen for a proteasome inhibitor. The invention also provides methods for determining baseline proteasome activity in a mammal.