Phenoxybenzylamine derivatives as ssris

Abstract

A compound of general formula (I) wherein R and R are H, C -C alkyl or (CH ) (C -C cycloalkyl) wherein d=0, 1, 2 or 3; or R and R together with the nitrogen to which they are attached form an azetidine ring; Z or Y is —SR and the other Z or Y is halogen or —R ; wherein R is C -C alkyl optionally substituted with fluorine; except that R is not CF ; or Z and Y are linked so that, together with the interconnecting atoms, Z and Y form a fused 5 to 7-membered carbocyclic or heterocyclic ring, and wherein when Z and Y form a heterocyclic ring, in addition to carbon atoms, the linkage contains one or two heteroatoms independently selected from oxygen, sulfur and nitrogen; R and R , which may be the same or different, are: A—X, wherein A=—CH═CH— or —(CH ) — where p is 0, 1 or 2; X is hydrogen, F, Cl, Br, I, CONR R , SO NR R , SO NHC(═O)R , OH, C alkoxy, NR SO R , NO , NR R , CN, CO R , CHO, SR , S(O)R or SO R ; or a 5- or 6-membered heterocyclic ring containing 1, 2 or 3 heteroatoms selected from N, S and O, optionally substituted independently by one or more R ; wherein R is hydroxy, C -C alkoxy, F, C -C alkyl, haloalkyl, haloalkoxy, —NH , —NH(C -C alkyl) or —N(C -C alkyl) .