The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 12, 2003
Filed:
Jul. 23, 2001
Richard Houben, Lanaken, BE;
Vincent Larik, Kerkrade, NL;
Medtronic, Inc., Minneapolis, MN (US);
Abstract
A sensing methodology is used based on measuring a physical response from a living structure as a result of a chemical compound stimulating this structure on the cellular level. Measurement of the heat response (calorimetry) from a group of pancreatic islets of Langerhans stimulated by glucose is proposed as a glucose biosensor. A novel biosensor concept is proposed acquiring physical response from living cells or cell clusters. In this particular case, membrane impedance of pancreatic B-cells, as a result of glucose stimulated cellular metabolism is used as physical readout. This method of physical assessment is made possible by growing genetically engineered pancreatic beta cells onto a substrate equipped with a set of interdigitated electrodes (IDEs).