The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 12, 2003

Filed:

May. 10, 2001
Applicant:
Inventors:

Frank H. Verhoff, Cincinnati, OH (US);

Robert A. Snow, West Chester, PA (US);

Gary W. Pace, Raleigh, NC (US);

Assignee:

SkyePharma Canada, Inc., Montreal, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
B02C 1/716 ; B02C 1/912 ;
U.S. Cl.
CPC ...
B02C 1/716 ; B02C 1/912 ;
Abstract

This invention describes a process for preparing a dispersion of solid particles of a milled substrate in a fluid carrier comprising the steps of (a) providing a plurality of large size milling media to the milling chamber of a media mill and forming a depth filter therefrom on an exit screen or separator in the milling chamber; (b) adding to said milling chamber a plurality of small size milling media optionally containing additional large size milling media, a conglomerate of a solid substance comprising a substrate to be milled and optionally one or more than one surface active substance, and a fluid carrier; (c) milling said conglomerate in said milling chamber to produce very small milled substrate product particles; and (d) separating said milled substrate particles suspended in said fluid carrier from the media through said depth filter; wherein the exit screen comprises openings of size S ; the large size media have a size distribution S of which all are larger than S ; the small size media have a size distribution S which are smaller than S ; the very small milled substrate particles have a size distribution S and are smaller than all of the small media; and the large size media and the small size media are essentially retained in the milling chamber.


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