The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2003
Filed:
Jul. 30, 2001
Alan D. King, Takoma Park, MD (US);
Richard E. Walters, Columbia, MD (US);
Cyto Pulse Sciences, Inc., Hanover, MD (US);
Abstract
An object of the invention is to provide a method for delivery of macromolecules into biological cells, such as Langerhans cells ( ) in the epidermis ( ) of a patient, which includes the steps of coating electodes ( ) in an electrode assembly ( ) with solid phase macromolecules to be delivered, such as a DNA, and/or RNA vaccine or a protein-based vaccine, attaching the electrode assembly ( ) having the coated electrodes ( ) to an electrode assembly holder ( ), providing a waveform generator ( ), establishing electrically conductive pathways between the electrodes ( ), and the waveform generator ( ), locating the electrodes ( ) such that the biological cells are situated therebetween, such as by penetrating the needle electrode ( ) into the epidermis ( ) above the epidermal basal lamina, and providing pulse waveform from the waveform generator ( ) to the electrodes ( ), such that macromolecule on the electrodes ( ) is driven off of the electrodes ( ), and delivered into the biological cells, such as the Langerhans cells ( ).