The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 05, 2003
Filed:
Mar. 08, 2001
Applicant:
Inventors:
David Wallach, Rehovot, IL;
Jacek Bigda, Gdansk, PL;
Igor Beletsky, Pushino, RU;
Igor Mett, Rehovot, IL;
Hartmut Engelmann, Munich, DE;
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/513 ; C12N 1/512 ; C12N 5/10 ; C12N 1/563 ;
U.S. Cl.
CPC ...
C12N 1/513 ; C12N 1/512 ; C12N 5/10 ; C12N 1/563 ;
Abstract
DNA encoding Antibodies to tumor necrosis factor receptors (TNF-Rs) are disclosed. The antibodies are preferably those which inhibit the cytotoxic effect of TNF but not its binding to the TNF-Rs. Most preferably, the antibodies bind to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor, which loop consists of the amino acid sequence Cys-185 to Thr-201 of SEQ ID NO:3.