The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2003
Filed:
Dec. 04, 2000
Paolo Cozzi, Milan, IT;
Pier Giovanni Baraldi, Ferrara, IT;
Italo Beria, Villamarzana, IT;
Marina Caldarelli, Milan, IT;
Maria Cristina Geroni, Milan, IT;
Giulia Pennella, Milan, IT;
Romeo Romagnoli, Milan, IT;
Pharmacia Italia S.p.A., Milan, IT;
Abstract
Compounds which are cinnamoyl distamycin derivatives of formula (I), wherein n is 2, 3, or 4; R is C -C alkyl or C -C haloalkyl; R and R , which are the same or different, are selected from hydrogen, C -C alkyl optionally substituted by one or more fluorine atoms; and C -C alkoxy; X is a halogen atom; Y and Z are the same or different and are selected, independently for each heterocyclic ring of the polyheterocyclic chain, from N and CH; B is selected from (a), (b), (c), (d), (e), (f), (g)and (h) wherein R , R , R , R and R are, independently from each other, hydrogen or C -C alkyl; or pharmaceutically acceptable salts thereof; provided that at least one of the heterocyclic rings within the polyheterocyclic chain is other than pyrrole; are useful as antitumor agents.