The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2003
Filed:
Aug. 25, 2000
Ping Huang, Mountain View, CA (US);
Chung Chen Wei, Foster City, CA (US);
Peng Cho Tang, Moraga, CA (US);
Chris Liang, Sunnyvale, CA (US);
John Ramphal, Union City, CA (US);
Bahija Jallal, Menlo Park, CA (US);
John Biltz, Newark, CA (US);
Sharon Li, Los Altos, CA (US);
Matt Mattson, Santa Clara, CA (US);
Gerald McMahon, Kenwood, CA (US);
Marcel Koenig, Burlingame, CA (US);
Sugen, Inc., South San Francisco, CA (US);
Abstract
The invention relates to trifluoromethyl sulfonyl and trifluoromethyl sulfonamido compounds and the physiologically acceptable salts and the prodrugs thereof. These compounds are expected to modulate the activity of protein tyrosine enzymes which are related to cellular signal transduction, in particular, protein tyrosine phosphatase, and therefore are expected to be useful in the prevention and treatment of disorders associated with abnormal protein tyrosine enzyme related cellular signal transduction such as cancer, diabetes, immuno-modulation, neurologic degenerative diseases, osteoporosis and infectious diseases. The invention also relates to the use of compounds containing fluoromethyl sulfonyl groups as phosphate mimics. These mimics may be used to inhibit, regulate or modulate the activity of a phosphate binding protein in a cell.