The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2003
Filed:
Jun. 09, 2000
Applicant:
Inventors:
Barbara Plaimauer, Vienna, AT;
Uwe Schlokat, Orth/Donau, AT;
Assignee:
Baxter Aktiengesellschaft, Vienna, AT;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 9/64 ; C12N 1/557 ; C12N 1/562 ; C12N 1/579 ; C12N 1/584 ;
U.S. Cl.
CPC ...
C12N 9/64 ; C12N 1/557 ; C12N 1/562 ; C12N 1/579 ; C12N 1/584 ;
Abstract
The present invention comprises a furin polypeptide having a modified amino acid sequence between the middle, homo-B-domain and the transmembrane domain compared to wild-type furin which retains proteolytic activity but is secreted at lower levels in cell culture compared to wild-type furin. Additionally, the invention includes nucleic acid molecules encoding such furin polypeptides, vectors and host cells comprising said nucleic acid molecules, compositions comprising said furin polypeptide and methods for producing such compositions.