The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2003
Filed:
Nov. 29, 2001
Applicant:
Inventor:
Kees Jalink, Heemstede, NL;
Assignee:
The Netherlands Cancer Institute, Amsterdam, NL;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G02N 3/353 ; C12N 1/500 ; C12N 1/509 ; C12N 1/563 ; C12N 1/570 ; C12N 1/574 ; C12N 5/00 ; C12N 1/502 ; G01N 2/176 ; G01N 3/300 ;
U.S. Cl.
CPC ...
G02N 3/353 ; C12N 1/500 ; C12N 1/509 ; C12N 1/563 ; C12N 1/570 ; C12N 1/574 ; C12N 5/00 ; C12N 1/502 ; G01N 2/176 ; G01N 3/300 ;
Abstract
The invention provides membrane molecule indicators, including polypeptides, encoding nucleic acid molecules and cells containing such polypeptides and nucleic acid molecules. The invention membrane molecule indicators are characterized in that fluorescence resonance energy transfer (FRET) between a donor fluorescent domain and an acceptor fluorescent domain indicates a property of the membrane molecule. Also provided are methods of using the invention membrane molecule indicators to determine a property of a membrane molecule, and to identify compounds that modulates a property of a membrane molecule.