The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 22, 2003
Filed:
Oct. 26, 2001
Frank Brown, Jr., West Lafayette, IN (US);
Robert Alan Forbes, Clinton, IN (US);
Arlette Faye Kreager, Avon, IN (US);
Michael Vincent Mullen, Fishers, IN (US);
Gregory Alan Stephenson, Fishers, IN (US);
Eli Lilly and Company, Indianapolis, IN (US);
Abstract
The present invention provides a process for producing cefaclor crystalline bulk material having a dissolution rate in a capsule of ≧80% in water in 30 minutes. One process route includes reducing the water content of cefaclor dihydrates or bulk material containing cefaclor dihydrate to produce a cefaclor form having a water content ≦2%. The cefaclor having the lower water content can then be rehydrated to a water content from 3.0 to 6.5% without adversely affecting the dissolution rate. An alternative process includes the addition of at least 0.05% of cefaclor related substances to inhibit conversion of the monohydate to the dihydate form.