The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 6593454 B1

PDF
Full Text
Expired
Date of Patent:
Jul. 15, 2003

Filed:

May. 24, 2001
Applicant:
Inventor:

Yie-Hwa Chang, St. Louis, MO (US);

Assignee:

Saint Louis University, Saint Louis, MO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 3/806 ; C07K 5/00 ; C07K 7/00 ;
U.S. Cl.
CPC ...
A61K 3/806 ; C07K 5/00 ; C07K 7/00 ;
Abstract

Methods are provided for detecting methionine aminopeptidase (MAP) activity and for detecting inhibitors of MAP. The methods utilize a peptide comprising an N-terminal methionine which can be cleaved from the peptide by MAP, and a C-terminal detection moiety which is released by a second peptidase only if the N-terminal methionine has been cleaved from the peptide. When the peptide is combined with MAP and the second peptidase, the detection moiety is released, while the addition of a MAP inhibitor will inhibit the release of the detection moiety. Reaction mixes, peptides, and kits which are useful for practicing the methods are also provided.


Find Patent Forward Citations

Chang, Yie-Hwa. (2003). Methods for identifying inhibitors of methionine aminopeptidases (U.S. Patent No. 6593454). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/6593454

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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