The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2003
Filed:
Oct. 22, 2002
Toshiya Moriwaki, Nara, JP;
Chantal Fürstner, Mühlheim, DE;
Bernd Riedl, Wuppertal, DE;
Jens-Kerim Ergüden, Wülfrath, DE;
Frank Böss, Wuppertal, DE;
Bernard Schmidt, Lindlard, DE;
Franz-Josef van der Staay, Lohmar, DE;
Werner Schröder, Wuppertal, DE;
Karl-Heinz Schlemmer, Wuppertal, DE;
Nagahiro Yoshida, Kyoto, JP;
Bayer Aktiengesellschaft, Leverkusen, DE;
Abstract
The invention relates to novel 3-oxo-2,1-benzisomazol-1(3H)-carboxamides (I), where R , R are the same or different and independently=H, halogen, C C alkyl C C alkoxy, C C perfluoroalkyl, or a group NR R ; R , R are the same or different and independently=C C alkyl, whose carbon chain is optionally interrupted by an O, S or NR and is optionally singly or severally substituted by C C cycloalkyl, C C alkoxy, OH, halogen or NR R ; C C cycloalkyl whose carbon chain is optionally interrupted by an O, S or NR and is optionally singly or severally substituted by C C alkoxy, OH, halogen or NR R , or R and R together with a nitrogen atom form a saturated or partially unsaturated - to -membered mono- or bi-cyclic heteocycle, which, optionally, contains up to two further heteroatoms, from N, O or S and is, optionally, substituted by C C alkyl, C C alkoxy, OH, halogen, COOR or NR R and X=O or S. The invention further relates to methods for production thereof and use thereof in the production of medicaments for the prophylaxis and/or treatment of diseases of the central nervous system, in particular, cognitive disorders, such as Alzheimer's disease and other forms of dementia, cerebral infarct, skull and brain trauma and pain.